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Clinical Trials/Clinical Studies
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Brueckl WM et al. Afatinib as first-line treatment in patients with EGFR-mutated non-small cell lung cancer in routine clinical practice. Ther Adv Med Oncol. 2021;13:17588359211012361.
de Marinis F et al. Afatinib in EGFR TKI-naïve patients with locally advanced or metastatic EGFR mutation-positive non-small cell lung cancer: Interim analysis of a Phase 3b study. Lung Cancer. 2021;152:127-134.
Janning M et al. Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM). Ann Oncol. 2022;33(6):602-615.
Miura S. UpSwinG: real-world, non-interventional cohort study on TKI activity in patients with EGFR mutation-positive (EGFRm+) NSCLC with uncommon mutations. ELCC 2021. Abstract 145P.
Park K et al. An open-label expanded access program of afatinib in EGFR tyrosine kinase inhibitor-naïve patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR mutations. BMC Cancer. 2021;21(1):802.
Passaro A et al. Afatinib in EGFR TKI-Naïve Patients with Locally Advanced or Metastatic EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Pooled Analysis of Three Phase IIIb Studies. Front Oncol. 2021;11:709877.
Popat S et al. Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon EGFR Mutations: A Retrospective International Cohort Study (UpSwinG). Oncologist. 2022;27(4):255-265.
Tamiya A et al. Cerebrospinal Fluid Penetration Rate and Efficacy of Afatinib in Patients with EGFR Mutation-positive Non-small Cell Lung Cancer with Leptomeningeal Carcinomatosis: A Multicenter Prospective Study. Anticancer Res. 2017;37(8):4177-4182.
van de Stadt EA et al. Identifying advanced stage NSCLC patients who benefit from afatinib therapy using 18 F-afatinib PET/CT imaging. Lung Cancer. 2021;155:156-162.
van Veggel B et al. Interim results of a phase II single arm trial combining afatinib with cetuximab in patients with EGFRex20ins positive NSCLC. J Clin Oncol. 2021;39(15_Supp):9112-9112.
Yang JC et al. Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6. Lancet Oncol. 2015;16:830-838.
Compassionate Use Programme/Expanded Access Programme (CUP/EAP)
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Case Studies/Case Series
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An N et al. Great efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report. Onco Targets Ther. 2019;12:7399-7404.
Armster K et al. Seltene Mutation im EGFR-Gen: EGFR-CCDC6-Fusion. Spectrum Onkologie. 2021;5:76-77.
Baptista Freitas M et al. Lung cancer metastases in the brain: Major response with afatinib. Chest. 2022;161(6_Supp):A570.
Bi H et al. Lung squamous cell carcinoma with rare epidermal growth factor receptor mutation G719X: a case report and literature review. Ann Transl Med. 2021;9(24):1805.
Cai Y et al. Successful treatment of a lung adenocarcinoma patient with a novel EGFR exon 20-ins mutation with afatinib: A case report. Medicine (Baltimore). 2019;98:e13890.
Caliman E et al. In regard to "Activity of EGFR TKIs in caucasian patients with NSCLC harbouring potentially sensitive uncommon EGFR mutations". Clin Lung Cancer. 2020;21(5):e363-e365.
Chan RT. Afatinib for an EGFR exon 20 insertion mutation: A case report of progressive stage IV metastatic lung adenocarcinoma with 54 months' survival. Asia Pac J Clin Oncol. 2018;(Suppl_1):7-9.
Chen D et al. A novel oncogenic driver in a lung adenocarcinoma patient harboring an EGFR-KDD and response to afatinib. Front Oncol. 2020;10:867.
Chen LC et al. A rare epidermal growth factor receptor H773L/V774M compound mutation in advanced non-small-cell lung cancer with poor response to epidermal growth factor receptor tyrosine kinase inhibitor. Respirol Case Rep. 2019;7:e00425.
Chiang C-L et al. Squamous cell carcinoma transformation after acquired resistance to osimertinib in a patient with lung adenocarcinoma harboring uncommon EGFR mutation. J Formos Med Assoc. 2020;119(9):1439-1441. 
Chikamori K et al. Treatment experience of a non-small cell lung cancer (NSCLC) patient harboring EGFR minor mutation L747P where afatinib was effective. Jpn J Lung Cancer. 2016;56:665.
Choy TS. First-line TKI treatment in a patient with advanced NSCLC and major uncommon EGFR mutations. MIMS Oncology (Hong Kong). 2021.
Citarella F. Response to: Successful afatinib rechallenge in a patient with nonsmall cell lung cancer harboring EGFR G719C and S768I mutations. Thorac Cancer. 2021;12(11):1791-1792.
Cortiula F et al. Non-small cell lung cancer harboring EGFR G724S mutation and exon 19 deletion responded to afatinib monotherapy after multiple lines of target therapies. Anticancer Drugs. 2022;33(9):960-962.
Coupkova H and Vyzula R. Afatinib in the treatment of advanced non-small cell lung cancer with rare EGFR (in exon 18-T179X) mutation - a case report. Klin Onkol. 2018;31:380-383.
Di Federico A et al. The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma-Letter. Clin Cancer Res. 2020;26(2):518-519.
Duan H et al. Effectiveness of afatinib after ineffectiveness of gefitinib in an advanced lung adenocarcinoma patient with a single EGFR exon 20 S768I mutation: a case report. Onco Targets Ther. 2018;11:2303-2309.
Endo S et al. A case report of a non-small-cell lung cancer patient who was EGFR-negative on a conventional test but was discovered to have an EGFR uncommon mutation on comprehensive genomic profiling and responded to afatinib. JJLC. 2020;60:429-433.
Fang W et al. Acquired EGFR L718V mutation and loss of T790M-mediated resistance to osimertinib in a patient With NSCLC who responded to afatinib. J Thorac Oncol. 2019;14:e274-e275. 
Fang W et al. Durable response of low-dose afatinib plus cetuximab in an adenocarcinoma patient with a novel EGFR exon 20 insertion mutation. J Thorac Oncol. 2019;14:e220-e221.
Fang W et al. Emergence of EGFR G724S after progression on osimertinib responded to afatinib monotherapy. J Thorac Oncol. 2020;15(3):e36-e37. 
Fang W et al. Molecular characteristics and response to diverse EGFR TKIs of NSCLC patients harboring EGFR E709 T710delinsX Mutation. J Thorac Oncol. 2021;16(3_Supp):S607-S608.
Fang W et al. Molecular characteristics and response to EGFR TKIs of EGFR L747 position mutation in lung cancer patients. J Thorac Oncol. 2021;16(3_Supp):S604.
Fang YF et al. Afatinib and osimertinib in lung adenocarcinoma harbored EGFR T751_I759delinsS mutation: A case report. Thorac Cancer. 2021;12(24):3429-3432.
Frega S et al. A triple rare E709K and L833V/H835L EGFR mutation responsive to an irreversible pan-HER inhibitor: A case report of lung adenocarcinoma treated with afatinib. J Thorac Oncol. 2016;11:e63-e64.
Gallant JN et al. EGFR kinase domain duplication (EGFR-KDD) Is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib. Cancer Discov. 2015;5:1155-1163.
Galli G et al. Uncommon mutations in epidermal growth factor receptor and response to first and second generation tyrosine kinase inhibitors: A case series and literature review. Lung Cancer. 2018;115:135-142.
Guida A et al. Ad hoc afatinib in an eldery lung cancer patient with EGFR exon 19 deletion L747-A750>P. Adv Respir Med. 2022;90(3):234-235.
Guo G et al. Next-Generation Sequencing Reveals High Uncommon EGFR Mutations and Tumour Mutation Burden in a Subgroup of Lung Cancer Patients. Front Oncol. 2021;11:621422.
Guo T et al. Two cases of non-small cell lung cancer patients with somatic or germline EGFR R776H mutation. Lung Cancer. 2021;161:94-97.
Han C et al. Afatinib, an effective treatment for patient with lung squamous cell carcinoma harboring uncommon EGFR G719A and R776C co-mutations. J Cancer Res Clin Oncol. 2022;148(5):1265-1268.
He C, Wang Y. Role of the EGFR-KDD mutation as a possible mechanism of acquired resistance of non-small cell lung cancer to EGFR tyrosine kinase inhibitors: A case report. Mol Clin Oncol. 2022;16(2):30.
He S et al. A novel EGFR G724S and R776H rare co-mutation response to afatinib in a patient with lung adenocarcinoma. J Thorac Oncol. 2021;16(3_Supp):S587-S588.
Hirose T et al. Extensive functional evaluation of exon 20 insertion mutations of EGFR. Lung Cancer. 2021;152:135-142.
Hochmair MJ et al. Complete remission to afatinib in a patient harboring a novel epidermal growth factor mutation in de novo small-cell lung cancer: A case report. Clin Lung Cancer. 2022;23(4):e289-e292.
Huang J et al. Non-small cell lung cancer harboring a rare EGFR L747P mutation showing intrinsic resistance to both gefitinib andosimertinib (AZD9291): A case report. Thorac Cancer. 2018;9(6):745-749.
Huang Q et al. Long-term survival in a patient with advanced lung adenocarcinoma harboring synchronous EGFR exon 18 G719A and BRAF V600E mutations and treated with afatinib: a case report. Anticancer Drugs. 2022;33(1):e730-e733.
Huang Y et al. Rare EGFR E709-T710delinsX: Molecular characteristics and superior response to afatinib treatment in NSCLC patients. Lung Cancer. 2022;172:117-123.
Ibrahim U et al. EGFR exon 18 delE709_T710insD mutated stage IV lung adenocarcinoma with response to afatinib. Lung Cancer. 2017;108:45-47.
Iida Y et al. Successful treatment of an elderly patient with an uncommon L861Q epidermal growth factor receptor mutation with low-dose afatinib: A case report. Thorac Cancer. 2020;11(2):447-450.
Ikeuchi T et al. Successful treatment of lung adenocarcinoma with epidermal growth factor receptor compound mutations involving exon 19 deletion and exon 20 insertion by afatinib. Intern Med. 2019;58:101-104.
Iwamoto Y et al. Efficacy of afatinib treatment for lung adenocarcinoma harboring exon 18 delE709_T710insD mutation. Jpn J Clin Oncol. 2019;49(8):786-788.
Jelli B et al. Complete Response to Afatinib of an EGFR Exon 18 delE709_T710insD-Mutated Stage IV Lung Adenocarcinoma. Eur J Case Rep Intern Med. 2021;8(8):002749.
Jiang H et al. EGFR L861Q and CDK4 amplification responding to afatinib combined with palbociclib treatment in a patient with advanced lung squamous cell carcinoma. Lung Cancer. 2020;145:216-218. 
Jiang Y et al. Sequential use of EGFR-tyrosine kinase inhibitors based upon EGFR mutation evolution achieves long-term control in a non-small cell lung cancer patient: a case report. Ann Palliat Med. 2021;10(6):7051-7056.
Kate S et al. Outcome of uncommon EGFR mutation positive newly diagnosed advanced non-small cell lung cancer patients: a single center retrospective analysis. Lung Cancer (Auckl). 2019;10:1-10.
Kim Y et al. First-line afatinib for non-small cell lung cancer in real-world practice. J Thorac Oncol. 2017;11(Suppl):S2209.
Kimura S et al. Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay. Cancer Sci. 2018;109:3657-3661.
Kobayashi IS et al. EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Preclinical Models and Clinical Scenarios. Cells. 2021;10(12):3561.
Kobayashi Y et al. EGFR exon 18 mutations in lung cancer: molecular predictors of augmented sensitivity to afatinib or neratinib as compared with first- or third-generation TKIs. Clin Cancer Res. 2015;21:5305-5313.
Kong C et al. Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report. BMC Pulm Med. 2020;20(1):135.
Kulkarni AA et al. Exceptional response to afatinib in a patient with persistent G719A EGFR-mutant NSCLC. Lung Cancer Manag. 2022;11(1):LMT54.
Kunimasa K et al. Dacomitinib overcomes afatinib-refractory carcinomatous meningitis in a lung cancer patient harbouring EGFR Ex.19 deletion and G724S mutation; a case report. Invest New Drugs. 2022;40(5):1137-1140.
Kunimasa K et al. Multiregional sequence revealed SMARCA4 R1192C mutant clones acquired EGFR C797S mutation in the metastatic site of an EGFR-mutated NSCLC patient. Lung Cancer. 2020;148:28-32.
Kutsuzawa N et al. Successful treatment of a patient with lung adenocarcinoma harboring compound EGFR gene mutations, G719X and S768I, with afatinib. Tokai J Exp Clin Med. 2020;45(3):113-116.
Li N et al. Pedigree analysis of the EGFR p.V1010M germline mutation in a family with a family history of non-small-cell lung cancer. Ann Transl Med. 2022;10(3):154.
Li T et al. Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations. Thorac Cancer. 2021;12(21):2924-2932.
Li Y et al. Meningeal metastasis patients with EGFR G724S who develop resistance to osimertinib benefit from the addition of afatinib. Transl Lung Cancer Res. 2020;9(5):2188-2190.
Liang SK et al. Afatinib is effective in the treatment of lung adenocarcinoma with uncommon EGFR p.L747P and p.L747S mutations. Lung Cancer. 2019;133:103-109.
Liang SK et al. Real-world experience of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma. Oncotarget. 2017;8:90430-90443.
Lin L et al. Response to Afatinib in a Patient with NSCLC Harboring Novel EGFR Exon 20 Insertion Mutations. Onco Targets Ther. 2020;13:9753-9757.
Liu Y et al. Lung adenocarcinoma harboring triple rare EGFR exon 18 mutations rapidly developed resistance to multiple therapies. Chemotherapy. 2022;67(4):248-252.
Long X et al. Great efficacy of afatinib in a patient with lung adenocarcinoma harboring EGFR L833V/H835L mutations: A case report. Onco Targets Ther. 2020;13:10689-10692.
Long Y et al. Durable complete response after afatinib and crizotinib in an advanced non-small cell lung cancer patient with EGFR L861Q mutation and acquired MET amplification: a case report. Ann Palliat Med. 2020;9(5):3609-3613.
Longo V et al. Successful treatment of triple EGFR mutation T785A/L861Q/H297_E298 with afatinib. Thorac Cancer. 2021;12(13):2031-2034.
Lu Z et al. EGFR (p. G719A+L747V)/EML4-ALK Co-alterations in Lung Adenocarcinoma with Leptomeningeal Metastasis Responding to Afatinib Treatment: A Case Report. Onco Targets Ther. 2021;14:2823-2828.
Lui J et al. Afatinib helped overcome subsequent resistance to osimertinib in a patient with NSCLC having leptomeningeal metastasis baring acquired EGFR L718Q mutation: a case report. BMC Cancer. 2019;19:702. 
Lv D et al. Response to afatinib in a patient with NSCLC harboring novel EGFR exon 20 insertion mutations. J Thorac Oncol. 2021;16(3_Supp):S634.
Lv D et al. The effect of afatinib and radiotherapy on a patient with lung adenocarcinoma with a rare EGFR extracellular domain M277E mutation and high PD-L1 expression. J Cancer Res Ther. 2022;18(2):587-589.
Ma C et al. Efficacy of afatinib for pulmonary adenocarcinoma with leptomeningeal metastases harboring an epidermal growth factor receptor complex mutation (exon 19del+K754E): A case report. Medicine (Baltimore). 2020;99(43):e22851.
Ma C et al. Tyrosine kinase inhibitors could be effective against non-small cell lung cancer brain metastases harboring uncommon EGFR mutations. Front Oncol. 2020;10:224. 
Martin J et al. Clinical impact of rare and compound mutations of epidermal growth factor receptor in patients with non-small-cell lung cancer. Clin Lung Cancer. 2019;20(5):350-362.e4.
Masuda T et al. Successful afatinib rechallenge in a patient with non-small cell lung cancer harboring EGFR G719C and S768I mutations. Thorac Cancer. 2020;11(8):2351-2356.
Mehta A et al. Rare epidermal growth factor receptor gene alterations in non-small cell lung cancer patients, tyrosine kinase inhibitor response and outcome analysis. Cancer Treat Res Commun. 2021;28:100398.
Messeha SS et al. A Rare Presentation of a Non-Asian Female With Metastatic Non-small-cell Lung Cancer Harboring EGFR L747P Mutation With Clinical Response to Multi-targeted Epigenetic and EGFR Inhibition. Anticancer Res. 2022;42(1):441-447.
Minari R et al. Afatinib therapy in case of EGFR G724S emergence as resistance mechanism to osimertinib. Anticancer Drugs. 2021;32(7):758-762.
Moran T et al. Clinical activity of afatinib in patients with non-small cell lung cancer harboring uncommon EGFR mutations: a Spanish retrospective multicenter study. Clin Lung Cancer. 2020;21(5):428-436.e2.
Morikawa K et al. A case of advanced adenocarcinoma genetically confirmed with EGFR/BRAF co-mutation in both primary and metastatic lesions. Ther Adv Med Oncol. 2021;13:17588359211053420.
Murano C et al. Osimertinib as treatment for EGFR exon 20 insertion-positive lung adenocarcinoma. EXCLI J. 2019;18:893-898. 
Nakamura T et al. Mechanisms of acquired resistance to afatinib clarified with liquid biopsy. PLoS One. 2018;13:e0209384.
Nasu S et al. Osimertinib treatment was unsuccessful for lung adenocarcinoma with G719S, S768I, and T790M mutations. Intern Med. 2018;57(24):3643-3645.
Ning M et al. Afatinib successfully treated leptomeningeal metastasis of lung adenocarcinoma in a patient with EGFR G719A mutation in detection of cerebrospinal fluid. Chinese Journal of Contemporary Neurology and Neurosurgery. 2020;20(6):551-555.
Niogret J et al. Primary resistance to afatinib in a patient with lung adenocarcinoma harboring uncommon EGFR mutations: S768I and V769L. J Thorac Oncol. 2018;13:e113.
Nuomi T et al. Therapeutic efficacy of osimertinib following afatinib for the rare EGFR mutation exon19 delL747_P753insS: A case report. Respirology. 2021;26:335-335.
Ohara G et al. Long-term survival with afatinib in a patient with lung adenocarcinoma harboring double uncommon EGFR L861Q and G719X mutations. In Vivo. 2020;34(3):1459-1462.
Oyamada Y et al. A Case of Advanced Lung Adenocarcinoma Harboring an Epidermal Growth Factor Receptor(EGFR) Exon 20 Insertion, D770_N771insSVD. Gan To Kagaku Ryoho. 2021;48(6):845-847.
Pang LL, et al. Efficacy and potential resistance mechanisms of afatinib in advanced non–small cell lung cancer patients with EGFR G719X/L861Q/S768I. Cancer. 2022;128(21):3804-3814.
Passaro A et al. Activity of EGFR TKIs in caucasian patients with NSCLC harboring potentially sensitive uncommon EGFR mutations. Clin Lung Cancer. 2019;20:e186-e194.
Patil T et al. Clinicopathologic characteristics, treatment outcomes, and acquired resistance patterns of atypical EGFR mutations and HER2 alterations in Stage IV non–small-cell lung cancer. Clin Lung Cancer. 2020;21(3):e191-e204.
Peled N et al. Subclonal therapy by two EGFR TKIs guided by sequential plasma cell-free DNA in EGFR-mutated lung cancer. J Thorac Oncol. 2017;12:e81-e84.
Puskás R et al. Ritka EGFR mutációt hordozó tüdő adenocarcinomában szenvedő beteg hosszútávú kezelése. Medicina Thoracalis. 2016;69:239-242.
Qian Y et al. EGFR-KDD with duplication of exons 18-26 responding to afatinib treatment in a patient with lung adenocarcinoma. J Thorac Oncol. 2021;16(3_Supp):S595.
Qin BD et al. The effectiveness of afatinib and osimertinib in a Chinese patient with advanced lung adenocarcinoma harboring a rare triple EGFR mutation (R670W/H835L/L833V): a case report and literature review. Onco Targets Ther. 2018;11:4739-4745.
Qin Y et al. Variability of EGFR exon 20 insertions in 24,468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors. Mol Oncol. 2020;14(8):1695-1704.
Qu F et al. An elderly advanced non-small cell lung cancer patient harboring rare epidermal growth factor receptor mutations L861R benefited from afatinib: A case report. Medicine (Baltimore). 2021;100(45):e27614.
Raez LE et al. EGFR L718V (+)/T790M (-) as a mechanism of resistance in patients with metastatic non-small-cell lung cancer with EGFR L858R mutations. Clin Lung Cancer. 2021;22(6):e817-e819
Raez LE et al. EGFR-RAD51 fusion: A targetable partnership originated from the tumor evolution? J Thorac Oncol. 2018;13:e33-e34.
Robichaux J et al. Structural classification of atypical EGFR mutations identifies 4 major subgroups with distinct patterns of drug sensitivity. J Thorac Oncol. 2021;16(3_Supp):S183-S184.
Rossi S et al. Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC. Curr Probl Cancer. 2022;46(1):100787.
Rubiera-Pebe R et al. Efficacy of tyrosine kinase inhibitors against lung cancer with EGFR exon 18 deletion: Case report and pooled analysis. Cancer Treat Res Commun. 2021;28:100407.
Satoh H et al. Response to afatinib in a common EGFR-mutated lung adenocarcinoma with a very rare combination of compound mutations. Turk Thorac J. 2022;23(5):364-365.
Saxon JA et al. EGFR L858M/L861Q cis mutations confer selective sensitivity to afatinib. J Thorac Oncol. 2017;12:884-889.
Sehgal K et al. Clinical benefit of tyrosine kinase inhibitors in advanced lung cancer with EGFR-G719A and other uncommon EGFR mutations. Oncologist. 2021;26(4):281-287.
Shen YC et al. Comparing the effects of afatinib with gefitinib or erlotinib in patients with advanced-stage lung adenocarcinoma harboring non-classical epidermal growth factor receptor mutations. Lung Cancer. 2017;110:56-62.
Song Z et al. Durable clinical benefit from afatinib in a lung adenocarcinoma patient with acquired EGFR L718V mutation-mediated resistance towards osimertinib: a case report and literature review. Ann Palliat Med. 2022;11(3):1126-1134.
Starrett JH et al. Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations. Cancer Res. 2020;80(10):2017-2030.
Sun C et al. Successful treatment of Afatinib plus Apatinib using for a lung adenocarcinoma patient with HER-2 V659D mutation: a rare case report. Anticancer Drugs. 2021;32(4):469-473.
Sun L et al. Afatinib in the treatment of brain metastases of lung cancer with one rare EGFR mutation: a two-case report. Anticancer Drugs. 2022;33(1):112-118.
Tamiya M et al. Successful treatment of an osimertinib-resistant lung adenocarcinoma with an exon 18 EGFR mutation (G719S) with afatinib plus bevacizumab. Invest New Drugs. 2021;39(1):232-236.
Tamura T et al. Limited effect of afatinib in a non-small cell lung cancer patient harboring an epidermal growth factor receptor K860I missense mutation: A case report. Thorac Cancer. 2021;12(11):1770-1774.
Tanaka I et al. Potential for afatinib as an optimal treatment for advanced non-small cell lung carcinoma in patients with uncommon EGFR mutations. Lung Cancer. 2019;127:169-171.
Ullas B et al. All EGFR mutations are (not) created equal: focus on uncommon EGFR mutations. J Cancer Res Clin Oncol. 2023;149(4):1541-1549.
Urban L et al. Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation. Clin Lung Cancer. 2021;22(1):e112-e115.
Van Acker L et al. Afatinib for the treatment of advanced non-small-cell lung cancer harboring an epidermal growth factor receptor exon 18 E709_T710delinsD mutation: a case report. J Med Case Rep. 2021;15(1):562.
van Kempen LC et al. Afatinib in osimertinib-resistant EGFR ex19del/T790M/P794L mutated NSCLC. J Thorac Oncol. 2018;13:e161-e163.
van Veggel B et al. Osimertinib treatment for patients with EGFR exon 20 mutation positive non-small cell lung cancer. Lung Cancer. 2020; 141: 9-13.
Wang P et al. Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18-18 and EGFR amplification: A case report. Front Oncol. 2022;12:918855.
Wang X et al. A Novel KIFSB-EGFR Fusion Variant in Non-Small- Cell Lung Cancer and Response to Afatinib: A Case Report. Onco Targets Ther. 2021;14:3739-3744.
Wang XF et al. Afatinib achieved remarkable disease control in a Chinese patient with lung adenocarcinoma harboring rare EGFR exon 18-25 kinase domain duplication. Am J Ther. 2020;27(5):e535-e537.
Watanabe M et al. The effectiveness of afatinib in a patient with advanced lung adenocarcinoma harboring rare G719X and S768I mutations. Intern Med. 2018;57:993-996.
Wei Y et al. Afatinib as a Potential Therapeutic Option for Patients With NSCLC With EGFR G724S. JTO Clin Res Rep. 2021;2(7):100200
Wei Y. et al. A Lung Adenocarcinoma Patient With a Rare EGFR E709_T710delinsD Mutation Showed a Good Response to Afatinib Treatment: A Case Report and Literature Review. Front Oncol. 2021;11:700345.
Wu JY et al. Effectiveness of treatments for advanced non-small-cell lung cancer with exon 20 insertion epidermal growth factor receptor mutations. Clin Lung Cancer. 2019;20(6):e620-e630.
Wu L et al. Durable response to afatinib in an advanced lung adenocarcinoma patient with an EGFR L858R/G729A compound mutation: a case report. Ann Transl Med. 2022;10(2):116.
Wu SG et al. The effectiveness of afatinib in patients with lung adenocarcinoma harboring complex epidermal growth factor receptor mutation. Ther Adv Med Oncol. 2020;12:1758835920946156.
Xu H and Shao C. KIF5B- EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma. Onco Targets Ther. 2020;13:8317-8321.
Xu J et al. NSCLC patients with rare EGFR mutations in exons 18 and 19 benefit from treatment with EGFR tyrosine kinase inhibitors. J Thorac Oncol. 2021;16(3_Supp):S633.
Yamaguchi T et al. Afatinib administration in a patient with non-small cell lung cancer harboring uncommon EGFR mutation G719A undergoing hemodialysis. Cancer Treat Commun. 2015;4:169-171.
Yang G et al. EGFR exon 20 insertion mutations in Chinese advanced non-small cell lung cancer patients: molecular heterogeneity and treatment outcome from nationwide real-world study. Lung Cancer. 2020;145:186-194. 
Yang X et al. Resolving resistance to osimertinib therapy with afatinib in an NSCLC patient with EGFR L718Q mutation. Clin Lung Cancer. 2020;21(4):e258-e260.
Yang Y et al. Osimertinib Resistance With a Novel EGFR L858R/A859S/Y891D Triple Mutation in a Patient With Non-Small Cell Lung Cancer: A Case Report. Front Oncol. 2020;10:542277.
Yu N et al. Successful Treatment of Afatinib Reversing Epidermal Growth Factor Receptor Exon19Deletion/G724S Mutation Resistance Guided by Protein-Drug Docking. Oncologist. 2021;26(11):e1903-e1908.
Zeng L et al. EGFR exon 18 DelE709_T710insD as an acquired resistance mechanism to afatinib in an advanced EGFR exon 18 E709H lung adenocarcinoma. J Thorac Oncol. 2018;13:e93-e95.
Zeng L et al. Identification of a Novel MET Exon 14 skipping variant coexistent with EGFR mutation in lung adenocarcinoma sensitive to combined treatment with afatinib and crizotinib. J Thorac Oncol. 2019;14:e70-e72.
Zhang C et al. Response to tyrosine kinase inhibitors in lung adenocarcinoma with the rare epidermal growth factor receptor mutation S768I and G724S: A case report and literature review. Thoracic Cancer. 2020;11(9):2743-2748.
Zhang H et al. Responsiveness to full-dose afatinib in a patient with lung adenocarcinoma harboring EGFR S768I and V769L mutations. J Thorac Oncol. 2019;14(2):e25-e27. 
Zhang L et al. Case Report: Afatinib Sensitivity in Rare EGFR E746_L747delinsIP Mutated LUAD With Peritoneal Metastases. Front Oncol. 2022;12:861271.
Zhang L-D et al. Osimertinib is an effective epidermal growth factor receptor-tyrosine kinase inhibitor choice for lung cancer with epidermal growth factor receptor exon 18-25 kinase domain duplication: report of two cases. Anticancer Drugs. 2022;33(1):e486-e490.
Zhang X et al. Afatinib response in a lung adenocarcinoma with novel compound S720F+L861R mutation in EGFR. Lung Cancer. 2020;148:170-172.
Zhang Y et al. Non-small-cell lung cancer with epidermal growth factor receptor L861Q-L833F compound mutation benefits from both afatinib and osimertinib: A case report. World J Clin Cases. 2021;9(27):8220-8225.
Zhao H et al. Afatinib as a potential therapeutic option for non-small cell lung cancer patients with EGFR G724S. J Thorac Oncol. 2021;16(3_Supp):S603.
Zhao L et al. Lung Adenocarcinoma Patient Harboring EGFR-KDD Achieve Durable Response to Afatinib: A Case Report and Literature Review. Front Oncol. 2021;11:605853.
Zhao Y et al. Significant Benefits of Afatinib and Apatinib in a Refractory Advanced NSCLC Patient Resistant to Osimertinib: A Case Report. Onco Targets Ther. 2021;14:3063-3067.
Zhao Y et. al. Efficacy of osimertinib in afatinib-resistant lung cancer harboring uncommon EGFR mutations: Case report and literature review. Clinical Lung Cancer. 2021;22(3):e466-e469.
Zhou T et al. EGFR L747P mutation in one lung adenocarcinoma patient responded to afatinib treatment: a case report. J Thorac Dis. 2018;10:E802-E805.
Zhu N et al. A patient of advanced NSCLC with a new EGFR Exon 19 insertion mutation and its response to EGFR-TKIs. J Coll Physicians Surg Pak. 2019;29(12):S126-S128.
Zoechbauer-Muller S et al. Case Report: Afatinib Treatment in a Patient With NSCLC Harboring a Rare EGFR Exon 20 Mutation. Front Oncol. 2020;10:593852.